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KeyGene reference: P201


The invention relates to the production of oligonucleotides, in particular targeting oligonucleotides or nucleic acid probes suitable for use, amongst others, in the field of nucleic acid detection. The invention provides for a method to accurately amplify mixtures of probes. Click on the image to see full size


Highly accurate amplification of probe mixtures is very beneficial for high throughput assays such as variation detection or genotyping. The invention produces high amounts of probe pools without changing their sequence composition or their respective ratios. KeyGene has proven that this method is capable of economically producing probe sets that can be successfully used in high multiplexed SNPSelect assays.


Oligonucleotide production is the bottleneck in many state-of-the-art detection methods, such as, but not limited to, genotyping methods that assist in crop breeding. The present invention that allows for the economic production of high-quality oligonucleotide probes is a game-changer.


Click on the link for an overview of the patent families in the European Patent Register: WO2019/238765

Please note that the European Patent Register may not be extensive and/or accurate, for which KeyGene is not responsible. Please contact your patent expert for further information.