KeyGene’s CropPedia to support international effort to combat crop-threatening weeds, headed by Colorado State University

Every multi-acre farmer and backyard gardener knows weeds are a constant, formidable foe of successful plant production. Across the globe, weed management demands billions of dollars in annual herbicidal treatments, or soil-damaging tillage of fields so crops can grow.

An international group of scientists and industry professionals, led by weed scientists at Colorado State University, have launched an ambitious new project aimed at improved management of the most intractable species of weeds in the world.

The International Weed Genomics Consortium, comprising 17 academic partners across seven countries, assembles a global community of experts who will develop genomic tools that fundamentally advance humanity’s approach to weeds and crops. The $3 million consortium is supported by $1.5 million in industry sponsorships and matching funds from the Foundation for Food & Agriculture Research (FFAR), a research and funding organization established by the U.S. Department of Agriculture.

The planned whole-genome approach to advance knowledge of specific weed species is a long time coming, according to project director Todd Gaines, associate professor of molecular weed science in CSU’s Department of Agricultural Biology.

Kochia weed

Large-scale weed control is usually accomplished by spraying herbicides, but weeds can adapt and evolve resistance to such treatments. Herbicides becoming less effective costs farmers billions of dollars, forcing increased use of unsustainable practices like soil tillage or even larger quantities of herbicides. In addition, there is a clear need to make herbicides more environmentally friendly and develop plants with fortified genetics that suffer less from emerging weed species.

“When you think about weeds, what makes them great is they are adapted to the harshest situations,” Gaines said. “They are the most cold-tolerant, the most salt-tolerant, the most heat-tolerant.”

Stress tolerance

By applying tools from genomics and molecular biology to advance weed science, that stress tolerance could possibly be applied to crops, and traditional management strategies could be reduced or retired, Gaines said. Genomic information also aids in the investigation of herbicide resistance mechanisms.

Consortium project manager and CSU research scientist Sarah Morran called weeds the “wild west of genetics” – which is why weeds are such a respectable and fascinating opponent.

“Yes, we want to help growers deal with weeds, but to me, it’s more about understanding them, and how we can target them by more integrated pest management strategies,” Morran said. “How can we set up these ecosystems where we can work with them a bit better, if we understand their genetics and understand how they are adapting and working?”

The consortium is now finalizing a list of 10 weed species for which they will sequence complete genomes. Among them are annual ryegrass (Lolium rigidum), which is especially problematic in Mediterranean climates like southern Australia, southern Europe and California; and tall fleabane (Conyza sumatrensis), which poses major issues in South America.

Matching support

FFAR’s support will enable the sequencing of additional species beyond the industry-appointed 10, including perennial weeds and aquatic varieties, to drive even more fundamental knowledge of weed biology.

“FFAR is proud to support this new effort to tame the threat of weeds,” said FFAR executive director Sally Rockey. “From genome sequencing to training the next generation of agriculture research scientists, the IWGC shows that new research can be the solution to many agriculture challenges.”

In addition to the genomes, the team will create user-friendly genome analytical tools and training, particularly to serve early-career weed scientists.

As a key component of the partnership, KeyGene will develop a tool based on the company’s internationally renowned, interactive genomics data management and visualization system, called CropPedia®. The cloud-based tool will enable the analysis of multiple genomes and access to many users at once, giving all partners the latest information in one place.

“We are looking forward to working with the International Weed Genomics Consortium partners to maximize the use of translating genomes into science, innovation and products, therewith contributing to a more resilient agricultural ecosystem,” said Marcel van Verk, team leader of crop data science at KeyGene.

Workforce development

Another goal of the consortium is to facilitate collaboration and workforce development within the emerging field of molecular weed science. Some of that development will take place through relationships with Historically Black Colleges and Universities, including North Carolina A&T State University Small Farms Resource and Innovation Center. Consortium leaders are seeking to increase the representation of traditionally underrepresented groups within the academic and industry pipeline of weed science.

Weeds in rice

The genomics consortium will complete the 10 weed genomes within three years, in close partnership with sponsoring company Corteva Agriscience, which will provide the expertise and resources for gold-standard genome assemblies. Corresponding annotations of these assemblies will be led by partners at Michigan State University.

“We’re proud to contribute our expertise in whole-genome sequencing to this important collaboration, which has the potential to yield industry-shifting insights to benefit farmers, consumers and the environment,” said Sam Eathington, chief technology officer at Corteva Agriscience. “Stubborn weeds are among the biggest challenges to farmer productivity. The outcomes of this collaboration will enable us to help farmers tackle those challenges in more precise and planet-friendly ways.”

Results and information will be shared via annual conferences made possible by USDA National Institute of Food and Agriculture funding. The first conference is slated for Sept. 22-24 in Kansas City, Missouri, with in-person and virtual options.

Partners

Founding industry sponsors of the International Weed Genomics Consortium are Bayer CropScience, BASF, Corteva Agriscience, Syngenta and CropLife International. Academic partners are CSU, Clemson University, Auburn University, University of Illinois, Oregon State University, Michigan State University, University of California-Davis, North Carolina A&T, University of Adelaide, University of Western Australia, Federal University of Rio Grande do Sul, Federal Rural University of Rio de Janeiro, Zhejiang University, Kyoto University, Seoul National University, Agricultural Research Organization (Israel), and Rothamsted Research.

The consortium is seeking additional corporate partnerships. Learn more: weedgenomics.org